Promethazine administered to some pregnant lady within two weeks of shipping and delivery may perhaps inhibit platelet aggregation in the newborn.
The combination of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric clients fewer than six years of age, simply because The mixture may well result in lethal respiratory depression Within this age populace. It is vital that promethazine with codeine syrup is calculated with an correct measuring unit (see Safety measures-Information For People).
Not less than just one Loss of life was documented within a nursing infant who was exposed to significant levels of morphine in breast milk because the mom was an extremely-speedy metabolizer of codeine.
Postmarketing situations of respiratory melancholy, which include fatalities happen to be described with utilization of promethazine in pediatric clients.
Life-threatening respiratory melancholy and Loss of life have transpired in young children who received codeine. Codeine is matter to variability in metabolism dependent on CYP2D6 genotype (explained beneath), which may lead to an increased exposure on the Lively metabolite morphine. Dependent on put up-marketing reports, little ones youthful than twelve several years previous look like much more prone to the respiratory depressant outcomes of codeine, significantly if there are threat aspects for respiratory despair.
Promethazine: Promethazine is actually a phenothiazine derivative which differs structurally through the antipsychotic phenothiazines because of the presence of the branched side chain and no ring substitution.
Other Unintended effects not listed may also take place in certain patients. When you observe any other outcomes, Examine with your Health care professional.
Promethazine and codeine need to be made use of all through pregnancy provided that the opportunity gain justifies the likely threat towards the fetus.
The impact of promethazine and/or codeine to the later on growth and progress from the newborn is unidentified.
Codeine: Narcotic analgesics, which include codeine, exert their Key results to the central anxious technique and gastrointestinal tract. The analgesic consequences of codeine are because of its central motion; nonetheless, the specific web sites of motion have not been determined, and also the mechanisms associated appear to be pretty sophisticated.
Given that recurrences of NMS are claimed with phenothiazines, the reintroduction of promethazine HCl needs to be carefully deemed.
This product or service may perhaps comprise inactive components, which might result in allergic reactions or other difficulties. Speak to your pharmacist For additional aspects.
Carefully evaluate the dose employing a Distinctive measuring machine/spoon. Do not utilize a domestic spoon as you may well not get the right dose.
Narcotics might create adverse reactions which may obscure the website scientific system of clients with head injuries.